Recently, a research team headed by Professor Zhang Chi—an Academician of both the Academia Europaea and the German Academy of Engineering Sciences, and affiliated with the School of Chemistry Science and Engineering at Tongji University—has, in collaboration with the Beijing Institute of Physics and Chemistry of the Chinese Academy of Sciences, the Australian National University, and other esteemed institutions, achieved notable advancements in the realm of deep-ultraviolet transparent polar organic sulfonate nonlinear optical crystals. The team introduced a pioneering "connectivity regulation" strategy, enabling the precise synthesis of a series of high-performance organic sulfonate crystals through meticulous control of anionic alkyl chains or counter cations. Notably, the Li[SO₃(CH₂)₂OH] crystal exemplified a harmonious optimization of deep-ultraviolet transparency and nonlinear optical performance, showcasing exceptional comprehensive optical attributes. These include a robust powder frequency-doubling effect, a substantial bandgap, and moderate birefringence. The pertinent findings were published in Angewandte Chemie International Edition, a renowned international academic journal in the fields of chemistry and materials, and were highlighted as both the cover article and a hot paper for that particular issue.