Recently, the internationally renowned journal Lab on a Chip spotlighted, as its cover story, the pioneering advancements achieved by the research team helmed by Researcher Liu Junshan and Professor Wu Mengxi from the School of Mechanical Engineering at Dalian University of Technology in the realm of microfluidic chips. This research zeroes in on the conundrum of achieving seamless liquid filling in blind-hole microchambers within centrifugal microfluidic chips, introducing an inventive approach that harnesses the design of tapered branched microchannels to modulate gas-liquid two-phase flow dynamics. Experimental findings reveal that the tapered configuration boosts fluid velocity by 60.57%, enhances flow stability by 66.78%, and attains a remarkable 99.17% success rate in liquid filling. It effectively transforms the problem of lingering air bubbles, typically encountered in conventional channels of uniform width, into an annular flow regime, facilitating efficient and non-destructive filling. This breakthrough not only surmounts the technical hurdles in miniaturizing treatment apparatuses for specific patient demographics, such as infants, but also furnishes robust technical backing for point-of-care testing scenarios, including nucleic acid detection and PCR amplification. The associated paper has been earmarked as a Hot Article for Lab on a Chip in 2025.