HLX22, an innovative HER2-targeted monoclonal antibody developed by Fuhong Hanlin, exhibits a unique synergy with trastuzumab. This combination enhances the efficacy of HER2 receptor endocytosis by a substantial 40%-80%, thereby amplifying the blocking effect. Preclinical studies and Phase II trials have convincingly demonstrated the remarkable efficacy of HLX22 in conjunction with trastuzumab and chemotherapy for the treatment of HER2-positive gastric cancer. Currently, the Phase III clinical trial of HLX22 is underway, marking a significant milestone as no similar dual-targeted therapy has yet been approved globally for this indication.