Plant diseases represent a significant threat to global agricultural output and food security, leading to annual losses amounting to billions of dollars. Developing crop varieties that are resistant to diseases stands as a fundamental strategy for disease prevention and management. The research team, led by Gao Caixia from the Institute of Genetics and Developmental Biology at the Chinese Academy of Sciences, introduced the innovative concept of "programmable synthetic plant immunity." By integrating various cutting-edge technologies, they established a design platform that facilitates the precise customization of immune receptors in plants. This groundbreaking achievement surpasses the constraints imposed by natural disease-resistance genes, offering a novel solution to tackle emerging diseases and adapt to variations in pathogens. The pertinent findings have been published in the esteemed journal Science.