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A team from the University of California, Berkeley, successfully simulated approximately 40 years of aging in human adipose and liver tissues within just four days using a micro-organ-on-a-chip system. By simulating the 'liver-fat interaction network' and comparing changes in newly generated tissues exposed to serum from elderly and young donors, the chip revealed that cells exposed to elderly serum exhibited aging characteristics such as chronic inflammation within four days. It also uncovered the 'contagious' nature of aging and gender differences. The study further utilized this chip to evaluate anti-aging therapies, finding oxytocin to be highly effective while rapamycin showed limited efficacy. Additionally, the research team has identified 11 novel biomarkers of aging and filed related patents, accelerating the commercialization process.
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