Researchers from the Tianjin Institute of Industrial Biotechnology at the Chinese Academy of Sciences (CAS) have achieved a significant advancement in plastic degradation technology. They have successfully engineered a novel method to efficiently break down polyurethane (PU) plastics, enhancing degradation efficiency by more than tenfold. By delving into the crystal structure of natural PU depolymerase, the team uncovered its high-efficiency degradation mechanism and further optimized it through enzymatic engineering to create a double mutant artificial enzyme with superior performance. This innovative technology boasts low energy consumption and minimal environmental pollution, facilitating multiple cycles of plastic recycling and presenting a groundbreaking solution for the disposal of waste PU plastics.