For the very first time, a research team has employed groundbreaking embryo splitting technology to successfully nurture a healthy live monkey from a single primate embryo and its genetically identical autologous embryonic stem cells. This pioneering endeavor not only produced healthy monkeys but also yielded a variety of genetically consistent stem cell lines, thereby opening new avenues in the realm of regenerative medicine. By splitting embryos at both the 4-cell and 8-cell stages, the team has demonstrated the efficacy of this technology in cultivating both monkeys and stem cell lines.
Autologous embryonic stem cells exhibit remarkable properties, including low heterogeneity and high genomic stability, while also inheriting the manipulative ease of traditional embryonic stem cells. Furthermore, this innovative technology has been successfully tested in human assisted reproductive embryos, signaling its potential for clinical translation. This advancement offers a promising solution to the challenge of immune rejection and lays a solid foundation for future applications in regenerative medicine.