Recently, a research team published groundbreaking findings in the prestigious journal Cell regarding the anti-aging mechanisms of exercise. For the first time, they conducted a systematic analysis of the distinct responses of the human body to both single and long-term regular exercise. This analysis revealed a pivotal "exercise-mimetic molecule," known as betaine. Cross-species studies have demonstrated that long-term exercise can enhance metabolism, bolster immunity, reduce inflammation, optimize gut microbiota, and elevate betaine levels in the kidneys. Betaine not only mirrors the myriad benefits of sustained exercise but also extends the healthy lifespan of aging mice, improves renal function, and enhances cognitive abilities. Its mechanism involves inhibiting the activity of the innate immune kinase TBK1 and decreasing the production of inflammatory factors. These findings provide a solid scientific foundation for the development of "exercise-mimetic drugs."