A team of scientists led by Professors Chen Peng and Wang Chu from Peking University has pioneered the innovative CAGE-Proxvivo technology. This groundbreaking approach seamlessly integrates machine learning with bioorthogonal cleavage reactions, offering unprecedented precision in regulating protein function across living cells and intact animal models. The technology triggers pyroptosis in tumor cells, bolstering anti-tumor immune responses. This achievement marks a significant advancement in the application of bioorthogonal cleavage reactions in vivo and introduces a novel tool for exploring dynamic biological processes and advancing precision medicine. The research findings have been published in the esteemed journal Cell.