With the RTX 40/50 series graphics cards driving the widespread adoption of the 12V-2x6 (12VHPWR) interface, gamers are confronted with a decision when building their systems: Should they opt for the graphics card's built-in power cable or the power supply's native direct cable? According to a survey conducted by Tech Overwrite, brand opinions can be broadly categorized into three groups. ASUS, MSI, and Gigabyte advocate for the use of the graphics card's built-in cable, highlighting its compatibility and stability advantages. On the other hand, SilverStone and Zotac recommend the power supply's native cable, particularly when the power supply is outfitted with a native 12VHPWR interface. Meanwhile, Sapphire, Thermaltake, and Gainward/Tongfang maintain that both approaches are viable, with the ultimate choice resting on user preference and installation habits.

Furthermore, the 12V-2x6 interface, an enhanced iteration of the 12VHPWR, boasts a maximum power output capacity of 675W. This upgrade aims to bolster power supply efficiency and safety, while also addressing prior concerns related to interface burnout. For 50-series graphics cards, NVIDIA advises utilizing power supplies that adhere to the PCle CEM 5.1 specification and ATX3.1 standard to guarantee stable performance.