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Recently, a research team helmed by Professor Huang Jinhai and Zhou Xingtao from the Eye & ENT Hospital of Fudan University published a study in the international academic journal Molecular Cell, a subsidiary publication of Cell. The study, titled "Engineered Ultra-Compact Fanzor-ωRNA System for Enhanced Gene Editing Activity," zeroes in on an exceptionally small “mini-scissors” derived from eukaryotes. Through coordinated engineering modifications to both the protein and ωRNA, the research substantially boosted editing efficiency in mammalian cells. In the realm of ocular research, the team broke new ground by establishing an A→G/C→T bidirectional base-editing platform. This innovative approach achieves gene editing without causing double-strand breaks, and it enables clear in vivo editing signals through a single AAV (Adeno-Associated Virus) one-time delivery.
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