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World's First Gene-Edited Pig Lung Transplant into Human Shows 216 Hours of Vitality and Functionality with Six Genetic Modifications
2025-08-27 /
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Author：小编
In a groundbreaking study, researchers meticulously modified the donor pig's genome with six precise edits. These edits effectively disabled the GTKO, CMAH, and B4GALNT2 genes, which are known triggers of immune rejection, while simultaneously introducing human protective genes like hCD46, hCD55, and hTBM to establish robust immune and coagulation protection mechanisms. This significant advancement offers crucial evidence for the feasibility of pig lung transplantation into humans, yet it still confronts formidable challenges, including the risks of post-transplant rejection and infection.
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