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A collaborative team from Osaka University and the Tokyo Institute of Science has pioneered a groundbreaking smart mRNA drug. Comprising three synthetic mRNAs, this innovative drug adeptly fulfills roles akin to biological logic circuits: detecting disease signals, regulating protein translation, and encoding therapeutic proteins. Experimental results have confirmed that this sophisticated system responds to disease-related molecules, such as those indicative of inflammation, and produces anti-inflammatory proteins on demand. This self-regulating drug dynamically tailors its efficacy to the body's evolving needs, positioning it as an ideal candidate for chronic disease treatment and mRNA vaccine optimization. This pioneering advancement signifies a new epoch in mRNA therapy, distinguished by its 'active sensing and response' capabilities.
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