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Researchers at the National Center for Nanoscience and Technology, a division of the Chinese Academy of Sciences, have unveiled a groundbreaking nano-degrader named mitoNIDs. Leveraging nano-induced proximity technology, this innovative tool brings tumor cell mitochondria into close proximity with the autophagy system, facilitating selective autophagic degradation. This process not only bolsters the immune attack efficacy of CD8+ T cells by upregulating MHC-I molecule expression and downregulating the anti-apoptotic protein BCL-XL, but also releases signaling molecules that activate T cells, thereby significantly enhancing anti-tumor immune response. In preclinical mouse studies, this method, when combined with immunotherapy, demonstrated remarkable efficacy, heralding the potential for future molecular-level precision treatments across a range of diseases.
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