For the first time, American scientists have successfully cultivated lung organoids equipped with comprehensive vascular networks using stem cells. The developmental trajectory of these organoids closely mirrors that of human lungs. This groundbreaking achievement not only enhances our understanding of early human development mechanisms but also lays a solid foundation for the creation of other vascularized organ models. By cultivating lung tissue and blood vessels concurrently, the research team endowed the organoids with a richer diversity of cell types, a more intricate three-dimensional structure, a higher cell survival rate, and developmental features that more closely resemble mature lungs. This model has already been utilized to study congenital lung diseases stemming from FOXF1 gene mutations, effectively mimicking vascular defects and abnormal lung tissue. Looking ahead, these lung organoids are poised to play a pivotal role in pulmonary vascular disease research, drug screening, and personalized medicine, potentially reducing the reliance on animal experimentation. Currently, the research team is striving to refine culture conditions to foster the development of more mature lung structures within the organoids.