Driven by technological advancements and policy initiatives, medical large models have embarked on a trajectory of rapid growth, yet their commercial potential remains largely untapped. A comprehensive report delves into the market landscape, application scenarios, and pathways to commercialization of these models, revealing a current market valuation of approximately 2 billion yuan, with projections indicating a breakthrough of 10 billion yuan by 2028. Nevertheless, the overall market penetration rate stands at less than 20%. Among the various types, imaging-based large models exhibit the most mature applications, while text-based models primarily cater to the medical IT sector. Biological large models contribute to drug development, and Traditional Chinese Medicine (TCM) large models are also experiencing robust growth. The report further contrasts the characteristics and commercialization progress of serious medical and auxiliary medical large models, offering insights into future trends, including the collaborative operation of large and small models and the widespread adoption of this technology.