This year signifies the sixth year of Cai Lei's valiant battle against amyotrophic lateral sclerosis (ALS). Cai Lei, a former vice president of JD.com, has been courageously fighting this debilitating disease. A few days ago, he hosted his inaugural live broadcast for the year, employing eye-controlled typing technology to engage with his audience. The typed messages were then converted into speech for playback. Through this live broadcast, Cai Lei aspires to embody and transmit a spirit of unwavering resilience, showcasing his persistent dedication to scientific research endeavors and ongoing communication with diverse stakeholders to propel research advancements. He shared that the 'AI Research Brain' dedicated to ALS has been functioning with remarkable efficiency, substantially expediting the research process. To date, nearly 40,000 pivotal literature articles have undergone review. Furthermore, he is currently engaged in collaborative efforts with scientists globally to hasten the validation process of potential drug candidates.